幽门螺杆菌阳性的慢性胃炎患者血清IL-8、IL-10的变化分析

Changes of IL-8, IL-10 in Chronic Gastritis Patients with Helicobacter Pylori Infection

目的探讨幽门螺杆菌阳性的慢性胃炎患者血清白细胞介素-8(IL-8)、白细胞介素10(IL-10)的变化。方法 52例幽门螺杆菌阳性的慢性胃炎患者作为观察组,30例健康人群你作为对照组,测定两组血清IL-8、IL10的含量。并观察观察组胃部炎症活动情况。结果观察组患者血清IL-8和IL-10的含量比正常对照组明显升高(P<0.01)。根据病情把观察组分为炎症活动正常、轻度、中度、重度四组,随着病情的加重血清IL-8和IL-10不段升高,各组间有明显差异(P<0.01)。结论幽们螺杆菌阳性的慢性胃炎患者血清IL-8和IL-10明显升高,并且与炎症的严重程度有密切的关系。

Objective To study the changes of interleukin-8（IL-8）,interleukin-10（IL-10） in chronic gastritis patients with Helicobacter Pylori（Hp） infection.Methods Fivety-two chronic gastritis patients with Hp infection were enrolled into the observation group,while thirty heathy people were enrolled into the control group.The IL-8 and IL-10 in serum were detected and the stomach inflammation activities were observed.Results The IL-8 and IL-10 in the observation group were higher than these in the control group（P0.01）.The patientsin the observation group were divided into four groups according to stomach inflammation activities.As the disease aggravated elevated,serum IL-8 and IL-10 were increased（P0.01）.Conclusions Helicobacter positive patients with chronic gastritis,serum IL-8 and IL-10 were significantly increased,and have a close relationship with the severity of inflammation.