4Reiter A,Schrappe M,Ludwig WD,et al.Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients.Results and conclusions of the multicenter trial ALL-BFM 86[J].Blood,1994,84(9):3122-3133.
5Evans WE,Relling MV,Boyett JM,et al.Does pharmacokinetic variability influence the efficacy of high-dose methotrexate for the treatment of children with acute lymphoblastic leukemia:what can we learn from small studies[J]? Leuk Res,1997,21(5):435-437.
6Sterba J,Valík D,Bajciová V,et al.High-dose methotrexate and/or leucovorin rescue for the treatment of children with lymphoblastic malignancies:do we really know why,when and how[J]? Neoplasma,2005,52(6):456-463.
7Evans WE,Petros WP,Relling MV,et al.Clinical pharmacology of cancer chemotherapy in children[J].Pediatr Clin North Am,1989,36(5):1199-1230.
8Evans WE,Crom WR,Abromowitch M,et al.Clinical pharma-codynamics of high-dose methotrexate in acute lymphocytic leukemia.Identification of a relation between concentration and effect[J].N Engl J Med,1986,314(8):471-477.
