2型糖尿病患者血清胱抑素C与下肢血管病变的关系

目的:探讨血清胱抑素C(CysC)与2型糖尿病下肢血管病变的关系。方法:收治2型糖尿病患者432例,对261例单纯糖尿病及171例2型糖尿病合并下肢血管病变患者,检测体重指数、血压、血糖、血脂、糖化血红蛋白、血清胱抑素C(CysC)浓度等相关指标,并分析血清胱抑素C(CysC)与2型糖尿病下肢血管病变的关系。结果:糖尿病并下肢血管病变组血清CysC水平明显高于无下肢血管病变组,差异有统计学意义(P<0.05)。2型糖尿病下肢血管病变与CysC、年龄、糖尿病病程、收缩压相关(P<0.01)。结论:本研究显示2型糖尿病下肢血管病变的发生发展除了与年龄、糖尿病病程、收缩压相关之外,还可能与胱抑素有关。

Objective：investigate the relationship between CystatinC（CysC） and lower extremity vascular disease caused by Type 2 Diabetes Mellitus（T2DM）.Method：We perform the analysis by collecting data from the 432 patients with T2DM in Department of Endocrinology of our hospital,261 of whom have been diagnosed with normal diabetes,with the rest 171 patients diagnosed with lower extremity vascular disease and T2DM.We have measured and collected the data from all the patients on body mass index,blood pressure as well as the concentration of blood glucose,blood lipids,glycosylated hemoglobin and CysC and analyzed the relation between CysC and lower extremity vascular disease.Results：show that patients with lower extremity vascular disease caused by T2DM have much larger concentration of CysC compared to those without lower extremity vascular disease,where the concen-tration difference has statistical significance（P 0.05）.Moreover,lower extremity vascular disease caused by T2DM has a strong interplay with CysC,age,the history of patients with Diabetes and diastolic pressure（P 0.01）.Conclusion：our research has indicated that lower extremity vascular disease caused by T2DM,in addition to being related to age,the history of patients with Diabetes and diastolic pressure,is very likely to be medically linked to CysC.