苯扎氯铵溶液用于烧伤创面的初步临床观察

Preliminary Clinical Observation of Benzalkonium Chloride on Burn Wounds

目的观察苯扎氯铵溶液对烧伤创面的抑菌作用及对创面愈合的影响。方法 2007年10月-2008年8月共观察30名成年住院烧伤患者,按自身对照分别使用苯扎氯铵和碘伏溶液换药,在第1、第7天换药前行细菌培养观察长期抑菌作用;10例在消毒后3 min再次行细菌培养,观察其即时消毒效果;第7天观察创面愈合率。结果苯扎氯铵组和碘伏组的长期、即时抑菌作用基本类似,用药第7天创面愈合率苯扎氯铵组高于碘伏组,差异有统计学意义。两组在换药时患者感觉均有疼痛感,未见伤口周围皮肤瘙痒和皮疹。结论苯扎氯铵溶液用于烧伤创面的抑菌作用与碘伏类似,但是苯扎氯铵溶液是阳离子表面活性剂,可清洁创面血污及有机物,有利于创面愈合,有可能替代碘伏成为烧伤创面基本用药。

Objective To observe the bacteriostasis of benzalkonium chloride solution （BZK） on burn wounds. Methods From October 2007 to August 2008 in our hospital ,30 adult burned patients were enrolled in the study. BZK or povidone iodine （PVP-iodine） were used on the wounds by self-control. Wounds culture was performed on the 1st and 7th day before dressing ex- change to observe the long term bacteriostasis. In order to observe the immediate bacteriostasis, wounds bacterial culture were con- ducted 3 min later after the disinfection was performed in 10 of them. The healing rate was observed on the 7th day. Results The long term or immediate bacteriostasis was similarly, however, the wounds healing rate in BZK group was significantly higher than that PVP-iodine group. The patients in both groups felt pain when dressed;there was no itching or rashes of the skin around the wound. Conclusion Benzalkonium chloride solution has a similar bacteriostasis for burn wounds with povidone-iodine. Benzalko- nium chloride solution is also a cationic surface active agent, it can clean the wounds bloodstained and organic matter, is condu- cive to wound healing, and is possible to substitute iodophor.