利血生联合辅酶A在治疗白细胞减少症中的临床应用

Clinical Application of Leucogen Combined with Coenzyme A in Treatment of Leukopenia

目的探讨利血生联合辅酶A治疗白细胞减少症的临床疗效。方法回顾分析一五二医院2008年3月-2012年3月收治的68例白细胞减少症患者临床资料,将患者按照随机数字法将其随机分为对照组和观察组,每组34例。对照组给予利血生治疗,20 mg/次,3次/d,连续服用4周。观察组在此基础上联合辅酶A给予治疗,200 U溶于500ml的5%葡萄糖注射液静脉滴注。连续治疗4周。结果观察组的显效及总有效明显高于对照组,无效率明显低于对照组。且两组患者治疗2周后的白细胞计数较治疗前明显升高(P<0.05或0.01),观察组治疗后2周及治疗4周后的白细胞计数明显高于对照组(P<0.05或0.01)。结论利血生联合辅酶A治疗白细胞减少症的临床疗效显著,不良反应少,值得在临床广泛推广。

Objective To investigate the clinical therapeutic efficacy of leucogen combined with coenzyme for leukopenia. Methods The clinical data of 68 cases with leukopenia admitted to our hospital from March 2008 to March 2012 were analyzed retrospectively. Accordance with the random, number,the patients were randomly divided into control group and observation group （34 cases in each group）. The control group was given leucogen, while the observation group was treated with coenzyme A and leucogen. Results The excellent rate and total effective rate of the observation group was significantly higher than those of the control group, no effect rate in the observation group was significantly lower than that in the control group. After two weeks of treatment, the white blood cell count was significantly increased in both groups （ P 〈 0.05 or 0.01 ）. The white blood cell count of the observation group was significantly higher（P 〈0.05 or 0.01 ） than those of the control group after 2 weeks and 4 weeks of treatment. Conclusion Leucogen and coenzyme A has a significant clinical effect on leukopenia, and fewer adverse reactions, and worth widely promoted in clinical practice.