β_2-微球蛋白在糖尿病肾病早期诊断中的价值

Early Diagnostic Value of β_2-microglobulin in Nonage Diabetic Nephropathy

目的本为旨在探讨β2-微球蛋白在糖尿病肾病早期诊断中的临床价值。方法将入选患者根据糖尿病病程分为DMⅠ组(病程≥5年)与DMⅡ组(病程<5年),利用免疫比浊法检测患者血清和尿液中β2-微球蛋白水平。结果与正常对照组相比,DMⅠ组和DMⅡ组糖尿病患者血清及尿液β2-微球蛋白水平均有显著性增加(P<0.05);在所检测的115份尿液样本中,尿白蛋白正常的患者(<20 mg/L)有45例,尿微量白蛋白(20～200 mg/L)有70例,所检测出其中尿β2-微球蛋白增高共78例,血清β2-微球蛋白水平增高共68例。结论β2-微球蛋白水平对糖尿病肾病的早期诊断具有重要的意义,可提高糖尿病早期肾功能损害的检出率,可在临床上广泛推广应用的检测方法。

Objective To investigate the clinical value of β2--microglobulin in the early diagnosis of diabetic nephropathy （DN）. Methods The eligible patients were divided into DN I group （ duration 〉 5 years） and DN H group （ duration 〈 5 years） according to the course duration of diabetes. The immune turbidimetry was used to detect the levels of β2--microglobulin in the serum or urine. Results The levels of β2--microglobulin in the serum or urine in DN I group and DN I1 group were both in- creased（P 〈 0.05 ） significantly as compared to the control group ; In the115 detected urine samples,45 cases were with normal level of urine white protein（ 〈 20 rag/L） ,70 cases with microalbumin（20 -200 rag/L） ,78 cases with increased β2--microglobu- lin in urine,68 cases with increased serum β2--microglobulin globulin. Conclusion The level of β2--microglobulin is of great sig- nificance for the early diagnosis of diabetic nephropathy. It can improve the detection rate of early renal dysfunction. This detection method can he widely promoted in clinical practice.