百草枯中毒患者细胞因子变化与临床治疗相关性研究

The Changes of Cytokine and Treatment of Patients with Acute Paraquat Intoxication

目的探讨急性百草枯中毒患者的血清细胞因子变化规律,研究其与临床治疗的相关性。方法采集2009年1月-2011年1月的20例百草枯中毒患者的临床资料进行回顾性分析,并将其设为A组观察组(n=20),同时并另设B组对照组(健康人,n=20),将两组进行静脉血和动脉血的采集检测及比较对照分析。结果患者血清细胞因子PDGF、IGF-1、TNF-α和IL-10等较对照组明显升高,差异有统计学意义(P<0.05),而IL-1β、IL-6相比较则变化不明显,差异无统计学意义(P>0.05)。结论在百草枯中毒发病机制中,细胞因子的变化对百草枯中毒造成的肺、肝和肾的损害具有显著的相关性,可能起到了重要的促进作用。

Objective To study the changes of cytokine in patients with acute paraquat intoxication,and to explore the corre- lation with the clinical treatment. Methods From January 2009 to January 2011, clinical data of 20 cases of paraquat intoxication of patients were collected and analyzed retrospectively. The patients were set as group A （observation group, n r-20）, and group B （ control group, n = 20）. Venous blood from the two groups was collected and compared. Results PDGF, IGF-1,TNF alpha and IL-10 in serum of group A increased more significantly than those of group B, the difference was statistically significant （ P 〈 0.05）, and IL-1β and IL-6 did not changed, no significant change between the two groups was observed （P 〉 0.05）. Conclu- sion The changes of cytokines had significant correlation with paraquat poisoning caused lung,liver and kidney damage, which may play an important role in promoting paraquat intoxication pathogenesis.