多囊卵巢综合征患者血清脂联素水平与胰岛素抵抗的关系

The relationship of plasma adiponectin level and insulin resistance in patients with polycystic ovary syndrome

目的:探讨多囊卵巢综合征(PCOS)患者血清脂联素水平与胰岛素抵抗的相关性。方法:58例P-COS患者根据体质指数分为肥胖组28例和非肥胖组30例,并选择30例正常同龄妇女为对照。比较血清脂联素(APN)、胰岛素(FINS)、瘦素(Leptin)及HOMA-IR水平。结果:PCOS组血清脂联素水平为7.24±2.36 ng/ml,明显低于对照组的14.86±3.67 ng/ml,P<0.01;多囊卵巢综合征肥胖组脂联素水平为5.8±2.8 ng/ml,明显低于非肥胖者的9.8±2.4 ng/ml,P<0.01;多囊卵巢综合征组肥胖、非肥胖者脂联素水平与体重指数(BMI)、胰岛素抵抗指数(HOMA-IR)、腰臀比(WHR)呈负相关,差异有统计学意义(P<0.01)。结论:PCOS患者血清脂联素水平降低,可能与肥胖、胰岛素抵抗相关,可以作为PCOS发生糖尿病远期并发症的预测指标。

Objective：To investigate potential association of plasma adiponectin with insulin resistance in polycystic ovary syndrome patients（PCOS）.Methods： PCOS patients（58） were divided into obese group（28） and non-obese group（30）.Normal females（30） in their reproductive ages were recruited as controls.Plasma adiponectin,leptin,fasting insulin and HOMA-IR were measured and the results were compared among the groups.Results： While the level of APN in PCOS group（7.24±2.36 ng/ml） was significantly lower than that in the controls（14.86±3.67 ng/ml,P0.01）.Furthermore,the APN level of obese group（5.8±2.8 ng/ml） was lower than that of non-obese group（9.8±2.4 ng/ml,P0.01）.A negative correlation（P0.01） between APN and other indices（BMI,WHR and HOMA-RI） was observed in both obese and non-obese groups.Conclusion： Lower APN level in PCOS patients was associated with obesity and insulin resistance,and thus it can be a prognostic index for diabetes.