血清联合检测PSA、FPSA和FPSA/TPSA在前列腺疾病鉴别诊断中的应用

Joint detection of serum PSA,FPSA and FPSA/PSA(F/T)in diagnosing prostate disease

目的:探讨血清联合测定前列腺特异抗原(PSA)、游离前列腺特异抗原(FPSA)和FPSA/PSA(F/T)在诊断前列腺疾病中的准确性及其意义。方法:采用化学发光法检测234例外科男性患者血清PSA及FPSA水平,并计算游离前列腺特异抗原/总前列腺特异抗原(F/T)比值。结果:前列腺疾病(前列腺炎、前列腺增生和前列腺癌)患者血清PSA和FPSA含量以及F/T值与健康人差异显著(P<0.01)。结论:血清联合检测PSA、FPSA和FPSA/TPSA能够较好地提高前列腺癌诊断的特异性和灵敏度,弥补单项检测的不足,对前列腺癌早期诊断、早期治疗都有重要的意义。

Objective：To investigate the accuracy and significance of combined determination of serum total prostate specific antigen（TPSA）,free prostate specific antigen（FPSA） and FPSA/TPSA（F/T） in the diagnosis of prostate disease.Methods： Serum PSA and FPSA levels in 234 male patients were detected by chemiluminescence method and FPSA/TPSA（F/T） was calculated.Results： Serum PSA and FPSA levels and F/T in patients with prostatic diseases had significant difference with those of healthy controls（P0.01）.Conclusion： Joint detection of serum PSA and FPSA levels and F/T can improve the specificity and sensitivity of prostate cancer diagnosis better,avoiding the disadvantages of single detection,having vital significance in early diagnosis and treatment of prostate cancer.