宁海县中医医院2010年-2011年铜绿假单胞菌的耐药性分析

Study on antimicrobial resistance of pseudomonas aeruginosa in Ninghai hospital of traditional Chinese medicine in 2010-2011

目的:了解铜绿假单胞菌的耐药性,为临床合理选择抗生素提供参考。方法:回顾性分析2010年1月-2011年12月本院临床分离的铜绿假单胞菌的分布情况及耐药性。结果:共分离出铜绿假单胞菌213株,其中痰标本中分离出铜绿假单胞菌最多,占86.9%;ICU、脑外科、呼吸内科分离的菌株数居前3位;铜绿假单胞菌对阿米卡星的敏感性较高,耐药率为11.7%,对庆大霉素和妥布霉素这类氨基糖苷类抗菌药物敏感性均较好,哌拉西林/舒巴坦对铜绿假单胞菌具有较好的抗菌活性,耐药率为19.7%。结论:铜绿假单胞菌对抗菌药物的耐药性呈上升趋势,加强医院感染病原菌的耐药性监测,对合理使用抗菌药物及减缓多药耐药菌的产生尤为重要。

Objective：To investigate the distribution and drug resistance of Pseudomonas aeruginosa separated in hospital,and to provide clinicians the laboratory evidence for guiding antibiotic therapy.Methods： The clinical distribution and the susceptibility test results of Pseudomonas aeruginosa isolated from our hospital from January,2010 to December,2011 were analyzed retrospectively.Results： Among 213 clinical isolates of Pseudomonas aeruginosa,the isolation rate from sputum was the highest（86.9%）.The isolates were mainly found in ICU,department of brain surgery and respiration department.They were highly resistant to cefoperazone/sulbactam（19.7%）,aminoglycosides： amikacin（11.7%）,gentamicin,tobramycin.Conclusion： The resistant rate of Pseudomonas aeruginosa is increasing year by year.Therefore,monitoring bacterial drug resistance is very important for the rational use of antibiotics and slowing the development of multi-drug bacteria.