摘要
目的比较分析自身免疫性肝炎、原发性胆汁性肝硬化和重叠综合征的临床特征。方法回顾性分析自身免疫性肝炎、原发性胆汁性肝硬化和重叠综合征患者的临床症状、体征、生化检查、免疫球蛋白、自身抗体、肝脏组织学等检查。结果3组均以女性患者多见,以乏力、黄疸、瘙痒、脾大等为主要临床表现;3组患者白蛋白水平均下降,以原发性胆汁性肝硬化组下降最明显(P〈0.05);3组患者总胆红素、直接胆红素、丙氨酸氨基转移酶、天门冬氨酸氨基转氨酶、碱性磷酸酶和γ-谷酰转移酶均有升高,以重叠综合征升高最明显(P〈0.05)。结论自身免疫性肝病患者的临床特征可能对早期诊断有重要意义;肝功能总胆红素、直接胆红素、丙氨酸氨基转移酶、天门冬氨酸氨基转氨酶、碱性磷酸酶和γ-谷酰转移酶等指标升高明显者需警惕重叠综合征的存在。
Objective To analyze the clinical features among patients with autoimmune hepatitis ( AIH), primary biliary cirrhosis (PBC) and overlap syndrome (AIH-PBC). Method To retrospectively analyze the clinical symptoms, physical signs, biochemistry, immunoglobulin, autoantibody, histopathology in patients with autoimmune liver diseases (including 120 AIH,49 PBC and 21 AIH-PBC cases). Results Women were affected more frequently than men. The most common symptoms were fatigue ,jaundice, pruri- tus and splenomegaly in the three groups. Serum albumin (ALB)levels decreased, especially in the PBC group. While the total bilirubin ( TBIL), direct bilirubin ( DBIL ), alanine aminotransferase ( ALT), aspar- tate aminotransferase (AST), serum alkaline phosphatase (ALP)and gamma-glutamyl transpeptidase (GGT) levels increased in the three groups,especially in the AIH-PBC group. Conclusion The clinical features might have significant importance on the early diagnosis of autoimmune liver diseases; If the TBIL,DBIL, ALT, AST, ALP, GGT levels were significantly higher, the presence of overlap syndrome should be alert.
出处
《临床内科杂志》
CAS
2012年第11期739-741,共3页
Journal of Clinical Internal Medicine
关键词
自身免疫性肝炎
原发性胆汁性肝硬化
重叠综合征
Autoimmune hepatitis
Primary biliary cirrhosis
Overlap syndrome
Clinical feature