中老年人轻度认知功能改变特点及与血脂水平关系的临床研究

Clinical research of the level of serum lipid in the elderly with mild cognitive impairment patients and their correlation

目的探讨中老年人轻度认知功能损害（MCI）的特点及与血脂水平的关系。方法对80例MCI患者和91例对照组应用简易精神状态量表（MMSE）和蒙特利尔认知评估量表（MOCA）进行认知功能评分及血脂水平的测定。结果（1）在MMSE中，MCI组的回忆能力及总分明显低于对照组（P〈0．05）；（2）在MOCA中，MCI组的视空间与执行功能、注意、语言、延迟回忆及总分明显低于对照组（P〈0．05）；（3）在血脂测定中，MCI组的血清总胆固醇（TC）和低密度脂蛋白胆固醇（LDL—C）的水平明显高于对照组（P〈0．05）。结论中老年MCI患者存在多个领域的认知功能损害，同时采用MMSE及MOCA量表，可以更加准确快速地筛查出Alzheimer病的高危人群。血清TC和LDL—C的升高与MCI的发病有一定相关性，给予降脂治疗对MCI及AD的防治可能有一定作用。

Objective To study in the elderly with mild cognitive impairment（MCI） characteris- tics and the relationship between lipid levels. Methods The 80 patients with MCI and 91 people selected as control group were assessed with mini-mental state examination（MMSE） and montreal cognitive assess- ment （MOCA） and were examed lipid. Results （ 1 ） In the MMSE test, recall ability and total score of the MCI group was significantly lower than control group（ P 〈 0.05 ）. （2） In the MOCA test, visual spatial and executive function, attention,language, delayed recall and total scores of the MCI group were significantly lower than control group（ P 〈 0.05 ）. （3）Serum total cholesterol（TC） and low-density lipoprotein choles- terol（LDL） level of MCI group was significantly higher than the control gronp（P 〈 0.05）. Conclusion Middle-aged patients with MCI have multiple areas of cognitive impairment, we will be able to detect high- risk groups in the AD quicker and accurately screening by using the MMSE and MOCA. Serum TC and LDL-C increased the incidence of MCI, given lipid-lowering therapy may have a role in the prevention and treatment of MCI and AD.