17例老年弥漫大B细胞淋巴瘤姑息化疗临床研究

Clinical study of palliative chemotherapy in 17 cases of elder late staged diffuse large B-cell lym- phoma patients

目的观察老年弥漫大B细胞淋巴瘤患者姑息化疗的近、远期疗效。方法收集17例老年弥漫大B细胞淋巴瘤患者，入院后酌情单用糖皮质激素或联合化疗，另取10例患者给予最佳支持治疗，每3周评价疗效、不良反应并随访3年。结果化疗组13例患者近期生活质量好转，最佳支持治疗组6例患者近期生活质量好转；化疗组生存期明显长于对照组，显示更好的生存获益（P〈0．05）。结论老年弥漫大B细胞淋巴瘤患者姑息化疗可以改善患者的临床症状，提高生存质量，延长生存期。

Objective To observe the clinical effects of palliative chemotherapy in 17 cases of elder late staged diffuse large B-call lymphoma （DLBCL） patients. Methods 17 cases of elder late staged DLBCL patients were selected to cure with palliative chemotherapy, and 10 elder late staged DLBCL patients were operated with the best surpport as the control group. The clinical effects and the quality of life and the life span were observed and compared once 3 weeks. Results The quality life of palliative chemotherapy group was more higher than before treatment and the life span of the group with chemotherapy was longer than the control group （ P 〈 0.05 ）. Conclusion Palliative chemotherapy has the remarkably effects of elder late staged DLBCL patients and can improve the quality life of paitients and the life span.