MCM7、Her-2、VEGF在乳腺癌组织中的阳性表达及其意义

Significance of MCM7and Her-2 and VEGF proteins expression in breast cancer

目的研究乳腺癌、乳腺腺瘤、瘤旁正常乳腺组织中MCM7、Her-2、VEGF的阳性表达情况,分析MCM7、Her-2、VEGF与乳腺癌病理特征的关系及三者在乳腺癌组织中的相互关系。方法应用免疫组化SP法检测70例乳腺癌、15例乳腺纤维腺瘤、15例瘤旁正常乳腺组织标本中MCM7、Her-2、VEGF的表达情况。结果乳腺癌组织中MCM7、Her-2、VEGF阳性表达率分别为85.7%、30.0%和67.1%,均明显高于良性对照组织中的阳性表达率(P<0.01),且在乳腺癌组织中三者的阳性表达呈正相关;MCM7、VEGF的阳性表达与乳腺癌临床分期和淋巴结转移有关,Her-2的阳性表达与乳腺癌临床分期无关,而与淋巴结转移有关。结论 MCM7、Her-2、VEGF是判断乳腺癌预后的重要指标,联合检测其阳性表达情况可为乳腺癌治疗和预后评估提供依据。

Objective To study MCM7、Her-2and VEGF expression in the breast cancer,benign adenomas,peritumoral normal breast tissue.To analyze the relationship between MCM7、Her-2and VEGF and pathological biological feature,and among the three in breast cancer.Methods MCM7、Her-2and VEGF proteins expression were detected with immunohistochemical SP in 70specimen of breast cancer,15 specimen of mammary gland fiber adenoma and 15specimen of peritumoral normal breast tissue.Results The positive rate of MCM7、Her-2and VEGF expression in breast cancer be 85.7%,30.2%and 62.5%respectively were significantly higher than those in the control group（P0.01） and positively correlated.MCM7、VEGF expression were associated with breast cancer staging and lymph node metastasis;Her-2expression were associated with the lymph node metastasis and have nothing to do with breast cancer staging.Conclusion MCM7,her2,and VEGF are important indexes of the prognosis in breast cancer.United detection MCM7、Her-2and VEGF expression could provide the basis for assessment of treatment and prognosis.