帕罗西汀与舍曲林治疗原发性早泄的临床应用对比观察

The comparison of clinical application of paroxetine and sertraline in the treatment of primary premature ejaculation

目的对比观察帕罗西汀与舍曲林治疗原发性早泄(PE)的临床效果,以探寻治疗原发性PE疗效相对稳定的药物。方法对88例入选的原发性PE患者采用国际勃起功能评分表和中国PE患者性功能评价表进行病情评估,然后分为观察组41例与对照组47例,分别口服帕罗西汀20mg与舍曲林50mg,1次/日,共6周,疗程结束后分别进行疗效评估并观察药物的副作用。结果治疗6周后,帕罗西汀能够显著延长PE患者的射精潜伏时间,患者的性满意度等指标显著改善。结论帕罗西汀治疗原发性PE较舍曲林更安全有效,疗效稳定,副作用低。

Objective To explore more stable medicines to treat primary premature ejaculation（PE）by compared the efficacy of paroxetine and sertraline.Methods 88patients of PE were evaluated with the international index of erectile function table（IIEF-5）and Chinese patients with PE index of sexual function（CIPE）and were devided into 41cased in the treatment group and 47cases in the control group.Paroxetine,20mg and sertraline,50mg were oral administration respectively and 1time a day,a total of six weeks.The effect and drug side effects were evaluated and compared.Results After 6weeks＇treatment,paroxetine could more significantly prolong IELT of the patients with PE,sexual satisfactions were more improved significantly compared with the patients in the sertraline group.Conclusion Paroxetine is safe and effective for PE patients,with stable efficacy and low side effect.