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环境化学物调控缺氧诱导因子在其所致毒效应中作用的研究进展 被引量：1

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摘要 缺氧诱导因子（hypoxia—inducible fatom，HIFs）是Semenza等于1992年在低氧诱导的肝细胞癌Hep3B细胞株的核提取物中发现的一种蛋白质，因发现该蛋白可调控多种低氧反应基因的转录水平．从而参与低氧反应信号转导过程，遂命名为缺氧诱导因子。HIFs作为调节氧稳态的核心转录因子，广泛地表达于哺乳动物的各种组织和细胞，
作者 徐媛 刘起展
机构地区 南京医科大学公共卫生学院卫生毒理学系现代毒理学教育部重点实验室
出处 《中华劳动卫生职业病杂志》 CAS CSCD 北大核心 2012年第12期962-966,共5页 Chinese Journal of Industrial Hygiene and Occupational Diseases
基金 国家自然科学基金（30872146,81072327） 教育部博士点基金（20103234110005） 江苏省高等学校自然科学重点项目（11KJA330002）,江苏省高等教育优势学科建设项目（2010）.
关键词 缺氧诱导因子 环境化学物 致毒效应 调控 低氧反应基因 B细胞株 肝细胞癌 信号转导
分类号 R114 [医药卫生—卫生毒理学]
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参考文献52

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二级参考文献61

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  • 8Ellis L,Hammers H,Pili R.Targeting tumor angiogenesis with histone deacetylase inhibitors[J].Cancer Lett,2009,280(2):145-153.
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中华劳动卫生职业病杂志
2012年 第12期

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