肿瘤乏氧检测方法研究进展

Investigation of hypoxia detection in tumor

自1955年Thomlinson和Gray对163例手术切除支气管癌的标本切片进行显微镜下观察，发现在正常增殖的细胞和坏死的细胞两者之间，有一层厚度为15～20μm的氧张力较低的乏氧细胞，从而证实恶性肿瘤内存在乏氧细胞以来，众多研究表明，乏氧细胞不仅能增加肿瘤对放化疗的抵抗作用，而且使得肿瘤具有更强的侵袭性，容易发生远处转移。如果能够准确地监测肿瘤的氧合状态，以指导治疗方案的制定和实施，将有助于提高肿瘤的治疗效果。

Summary Hypoxia could not only induce tumor chemoradiotherapeutic resistance, but also cause strong m- vasiveness which make tumor inclined to recurrence and metastasis. With regard to the detection of oxygenation condition in tumor tissue, there are many methods, but each has its advantages and disadvantages. Accurate moni- toring of tumor oxygenation state plays an important role in therapeutic schedule formulation and implementation Which would improve curative effect of tumor.