深圳市戊型肝炎血清流行病学调查

Seroepidemiological Investigation of Hepatitis E Virus in Shenzhen City

目的了解深圳市戊型肝炎抗-HEV IgG抗体水平,为制定预防控制措施以及戊肝疫苗免疫策略提供依据。方法采用多阶段分层随机抽样法,全市按行政级别由高到低分为区、街道办事处、工作站3层,每层均采取随机抽样的原则进行抽样,对深圳市8个区1～59岁3771名居民戊型肝炎抗体水平进行调查研究,采用酶联免疫吸附试验检测戊型肝炎IgG抗体。结果本次调查共检测3771人,男性1834人,抗体阳性率为23.72%,女性1937人,抗体阳性率为23.64%。其中深圳户籍人口1389人,抗体阳性率为19.08%;非深圳户籍人口2382人,抗体阳性率为26.36%。不同年龄组人群抗体阳性率差异有统计学意义,且随着年龄的增长抗体阳性率呈增长趋势。不同文化程度人群抗体阳性率差异有统计学意义,且文化程度高的人群抗体阳性率最低,为28.50%。结论深圳市人群中抗-HEV IgG流行率与年龄、居住地类型、文化程度有关,而与性别无关。深圳市戊肝的流行趋势不容忽视,应加强对戊肝的监测。

Objective To understand the anti-HEV antibody levels of hepatitis E in Shenzhen city, and provide the evidence for the prevention, control and the immunization strategies for the hepatitis E. Methods Multiple stage stratified chester random sampling method was used in this research.People were divided to three levels according to the administrative level by this method.A total of 3 771 citizens from 8 regions of Shenzhen city aged 1-59 years old were tested for anti-HEV IgG by enzyme immunoassay （ELISA）. Results The positive rate of anti-HEV IgG in male and female were 23.72% （ 1 834/3 771 ） and 23.64% （ 1 937/3 771 ）, respectively. The positive rate of anti-HEV IgG was 19.08% （1 389/3 771） in residences of Shenzhen,while it was 26.36% （2 382/3 771） in non-residences. The positive rate of anti-HEV IgG increased with age, and was related to education attainment. People with higher education level had the lowest positive rate of anti-HEV IgG （28.50%）. Conclusion The prevalence of hepatitis E in Shenzhen should never be neglected. It is necessary to pay more attention to the surveillance of the hepatitis E.