辛伐他汀治疗类风湿性关节炎合并骨质疏松症的疗效分析

Analysis of curative effect of simvastatin in the treatment of rheumatoid arthritis with osteoporosis

目的探讨辛伐他汀治疗类风湿性关节炎合并骨质疏松症的疗效。方法选取在笔者所在医院接受治疗的36例类风湿性关节炎合并骨质疏松患者作为观察组,口服辛伐他汀、美洛昔康,并联合使用甲氨喋呤和柳氮磺胺吡啶肠溶片治疗,接受常规补钙及常规护理的29例类风湿性关节炎合并骨质疏松患者作为对照组。对腰椎进行CT扫描。结果所有患者接受治疗后关节压痛情况、肿胀程度、关节功能评分等都出现了明显的好转,观察组治疗后的骨密度明显高于治疗前,观察组疗效明显优于对照组,差异均有统计学意义(P<0.05)。结论他汀类药物是现阶段已知的唯一可以兼顾促进骨形成和抑制骨吸收的药物,且该药价格低、副作用少,经济效益高,值得推广应用。

Objective To explore the effect of simvastatin in the treatment of rheumatoid arthritis with osteoporosis. Methods 36 patients of observation group of rheumatoid arthritis with osteoporosis in our hospital were treated by simvastatin and meloxicam and combined with methotrexate and sulfasalazine enteric-coated metformin hydrochloride.29 patients of control group of rheumatoid arthritis with osteoporosis were treated by conventional calcium and routine nursing care. To take CT scan for all patients. Results The Joint tenderness, swelling degree, joint function scale of all patients after treatment were better than before, and the bone mineral density of observation group was higher than prior treatment （ P 〈 0.05 ）. The effect of observation was better than the control group（P 〈 0.05）. Conclusion Statins are currently known as both promoting bone formation and inhibit bone absorption of the drug, and the drug prices is low, less side effects, high economic benefit, and it is worthy of popularization and application.