国产氯吡格雷治疗非ST段抬高型急性冠脉综合征临床疗效观察

Clinical curative effect observation of domestic clopidogrel in treating non-ST-segment elevation acute coronary syndrome

目的观察国产氯比格雷治疗非ST段抬高的急性冠脉综合征患者的疗效。方法选择符合入选条件的非ST段抬高ACS患者120例,随机分为泰嘉组(加服国产氯吡格雷)、波立维组(加服进口氯吡格雷)。观察胸痛消失率、心电图变化、药物安全性。结果胸痛在两组治疗后均较治疗前明显缓解,心电图ST段两组在治疗后较治疗前明显改善。但两组之间的疗效及主要副作用差异无统计学意义(P>0.05)。结论服用国产氯吡格雷对非ST段抬高的ACS患者安全有效。

Objective To observe the efficiency and safety of domestic clopidogrel in the treatment of patients with non- ST-segment elevation acute coronary syndrome. Methods 120 patients who were qualified for the requirements of this study were enrolled and randomly divided into talcom group and plavix group. The drug safety, angina and the ECG changes were observed. Results Most of patients from both groups got cured from angina, and ECG ST-segment got significant improvement. But differences of curative effect and main by-effect between two groups was not statistically significant. Conclusion This study demonstrate that the effect of domestic clopidogrel for non-ST-segment elevation acute coronary syndrome is equivalent to the plavix with similar low negative effect and high safety.