糖类抗原检测在非小细胞肺癌诊疗中的应用

Application of the carbohydrate cantigen detection for diagnosis and treatment of non small cell lung cancer

目的探究糖类抗原检测用于非小细胞肺癌诊疗的临床意义。方法使用多种肿瘤标志物蛋白芯片检测系统,对2008年9月～2012年4月已确诊的158例非小细胞肺癌患者的血清CA19-9、CA242、CA125、CA153水平进行测定,并与肺部良性病变对照组和健康对照组进行比较。结果肺癌组的CA19-9、CA242、CA125、CA153血清水平高于肺部良性病变对照组和健康对照组,而且CA19-9、CA125、CA153血清水平差异尤为明显;肺腺癌患者在CA19-9、CA125血清水平阳性检出率高于肺鳞癌患者,差异有统计学意义(P<0.05);4种糖类抗原阳性检出率与分期的早晚成正相关,CA125和CA153的早期的阳性检出率较CA19-9和CA242高且差异有统计学意义(P<0.05)。结论糖类抗原检测用于非小细胞肺癌诊疗具有可观的临床价值。

Objective To explore the clinical significance of the carbohydrate antigen detection for diagnosis and treatment of non small cell lung cancer. Methods The levels of serum CA19-9,CA242,CA125,CA153 of 158 cases of confirmed patients with non small cell lung cancer were measured by using of multiple tumor marker protein chip detection system and were compared with benign lung lesions and healthy people in the control group. Results The levels of serum CA19-9, CA242,CA125,CA153 in the lung cancer group were higher than benign lung lesions and healthy people in the control group,but there were particularly apparent difference in the levels of serum CA19-9,CA125 and CA153.The positive rates of serum CA19-9 and CA125 in the patients with lung adenocarcinoma were Significantly higher than that in patients with squamous cell carcinoma of the lung （P 〈 0.05）.The positive rates of 4 kinds of carbohydrate antigen had a positive correlation with staging and the early positive rates of CA125 and CA153 were higher than that of CA19-9 and CA242 （P 〈 0.05）. Conclusion The carbohydrate antigen detection for diagnosis and treatment of non small cell lung cancer has considerable clinical value.