急性冠状动脉综合征患者血清胱抑素C、白细胞介素-6的变化

Levels of serum Cystatin C and IL-6 and its clinical significance in patients with acute coronary syndrome

目的:分析急性冠状动脉(冠脉)综合征(ACS)患者血清胱抑素C(CysC)和白细胞介素6(IL-6)水平变化及临床意义。方法:选择2010-08-2011-12我院住院患者102例,分为急性心肌梗死(AMI)组30例、不稳定型心绞痛(UAP)组45例、稳定型心绞痛(SAP)组27例;另选取77例非冠心病(CHD)住院患者为非CHD组。分别测定各组血清CysC与IL-6水平,组间进行两两比较。结果:UAP组血清CysC水平明显高于SAP组及非CHD组;AMI组血清CysC水平较UAP及SAP组低,与非CHD组比较差异无统计学意义。IL-6水平分别为:AMI组>UAP组>SAP组>非CHD组。结论:CysC与IL-6可能与ACS的发生发展有关,早期联合检测CysC与IL-6对预测ACS的发生和发展有一定指导意义。

Objective：To study the change of serum Cystatin C （CysC） and IL-6 levels and its clinical signifi- cance in patients with acute coronary syndrome （ACS）. Method： One hundred and two patients with CHD from August 2010 to December 2011 were selected and divided into acute myocardial infarction （AMI） group, unstable angina （UAP） group and stable angina （SAP） group. Seventy-seven patients without CHD were selected in non- （THD group. The level of CysC and IL-6 were detected. Result：The level of CysC in UAP group was higher than that in non-CHD group and SAP group （P〈0.05）. The level of CysC in AMI group was lower than that in UAP group and SAP group （P〈0.05）, and there was no significant difference between in non-CHD group and AMI group （P〈0.05）. The levels of IL-6 from high to low order were AMi group, UAP group, SAP group and non- CHD group. Conclusion：The expression of CysC and IL-6 may play a key role in the occurrence of ACS. Detecting CysC and IL-6 levels have a certain guiding significance in prediction of ACS occurrence.