肿瘤血管生成的PET检测

PET imaging for evaluating tumor angiogenesis

肿瘤血管生成作为肿瘤的主要特征，在肿瘤生长和转移中起着重要作用，为肿瘤治疗提供了新策略。通过标记血管生成相关的受体、多肽、激酶或细胞外基质蛋白，形成高亲和力的分子探针，与肿瘤血管生成过程中产生的特异性靶分子结合，从而显示包括整合素、VEGF／VEGFR、基质金属蛋白酶（MMPs）等与血管生成关系密切的特征性血管生成因子，可从分子水平对肿瘤新生血管及血管靶向治疗疗效进行无创性检测。笔者就肿瘤血管生成PET影像学检测研究进展及未来发展作一综述。

Angiogenesis, a main characteristic in tumors, plays an important role in tumor growth and metastasis, which provides a new strategy for tumor treatment. By marking angiogenesis-related recep- tors, polypeptides, kinases or extracellular matrix proteins as high affinity molecular probes, PET imaging can noninvasively display integrins, VEGF/VEGFR, matrix metalloproteinases （MMPs） and closely moni- tor tumor angiogenesis and vascular-targeted treatments on the molecular level. In this paper, research pro- gress and future development of PET imaging for evaluating tumor angiogenesis are reviewed.