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非小细胞肺癌分子靶向治疗的研究进展 被引量:6

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摘要 0引言 肺癌是现今恶性肿瘤中发病率和死亡率最高的癌症,每年全世界有138万患者死于肺癌。其中,非小细胞肺癌(NSCLC)病例占全部肺癌病例的80%~85%。NSCLC恶性程度高,容易复发转移,且一般确诊时病情已发展到晚期。
出处 《肿瘤防治研究》 CAS CSCD 北大核心 2012年第12期1507-1513,共7页 Cancer Research on Prevention and Treatment
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参考文献47

  • 1Ferlay J, Shin HR, Bray F, et al. Parkin DM. Estimates of world wide burden of cancer in 2008: GLOBOCAN 2008[J]. Int J Cancer,2010,127(12) :2893-917.
  • 2Jemal A, Siegel R, Ward E, et al. Cancer statistics[J]. CA Cancer J Clin,2007,57 ( 1 ) : 43-66.
  • 3Wang F,Wang S,Wang Z,et al. Phosphorylated EGFR expression may predicts outcome of EGFR-TKIs therapy for the advanced NSCLC patients with wild-type EGFR[J]. J Exp Clin Cancer Res, 2012,31 ( 1 ) : 65.
  • 4Maemondo M, Minegishi Y, Inoue A, et al. First-line gefitinib in patients aged 75 or older with advanced non-small cell lung cancer harboring epidermal growth factor receptor mutations (NEJ 003 study) [J]. J Thorac Oncol, 2012,7 (9):1417-22.
  • 5Oizumi S,Kobayashi K,Inoue A,et al. Quality of life with gefitinib in patients with EGFR-mutated non-small cell lung cancer: quality of life analysis of north east Japan study group 002 trial[J]. Oncologist, 2012,17 (6) : 863-70.
  • 6Kim ES, Hirsh V, Mok T, et al. Gefitinib versus doeetaxel in previously treated non-smalbeell lung cancer(INTEREST): arandomised phase Ⅲ trial [J]. Lancet, 2008, 372 (9652): 1809-18.
  • 7Fukuoka M,Wu YL,Thongprasert S,et al. Biomarker analyses and final overall survival results from a phase Ⅲ,randomized, open-label,first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients'with advanced non-small- cell lung cancer in Asia (IPASS) [ J ]. J Clin Oncol, 2011,29 (21): 2866-74.
  • 8Mitsudomi T, Morita S, Yatabe Y, et al. Gefitinib versus cisplatin plus docetaxel in patient with non small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405) : an open label, randomised phase 3 trial[J]. Lancet Oncol, 2010,11 (2) : 121-8.
  • 9Tony SK,Manolo D, Raffaele C. Clinical outcomes with Erlo tinib in patients with epidermal growth factor receptor mutation(NEJGSG002) [J]. Drugs,2012(72) :3-10.
  • 10Zhang L, Ma S, Song X, et al. Gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer(INFORM: C-TONG 0804) : a multicentre,double blind randomised phase 3 trial[J]. Lancet Oncol,13(5) :466-75.

二级参考文献57

  • 1杨林,王金万,汤仲明,刘秀文,黄镜,李树婷,董英,张和平,薛岚,储大同,孙燕.重组人血管内皮抑制素Ⅰ期临床研究[J].中国新药杂志,2004,13(6):548-553. 被引量:154
  • 2周清华,孙燕.加强我国肺癌分子靶向治疗基础和临床研究[J].中国肺癌杂志,2004,7(4):267-269. 被引量:51
  • 3杨林,王金万,崔成旭,黄镜,张和平,李树亭,孙燕.重组人血管内皮抑制素YH-16联合用药治疗晚期非小细胞肺癌的多中心Ⅱ期临床试验[J].中国新药杂志,2005,14(2):204-207. 被引量:116
  • 4王金万,孙燕,刘永煜,于起涛,张沂平,李凯,朱允中,周清华,侯梅,管忠震,李维廉,庄武,王东林,梁后杰,秦凤展,卢辉山,刘晓晴,孙红,张燕军,王杰军,罗素霞,杨瑞合,涂远荣,王秀问,宋恕平,周静敏,游丽芬,王竞,姚晨.重组人血管内皮抑素联合NP方案治疗晚期NSCLC随机、双盲、对照、多中心Ⅲ期临床研究[J].中国肺癌杂志,2005,8(4):283-290. 被引量:625
  • 5Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevaxizumab for non-small-cell lung cancer. N Engl J Med, 2006, 355(24): 2542-2550.
  • 6Laurie SA, Arnold A, Shepherd FA, et al. National Cancer Institute of Canada clinical trials group study BR.24, a randomized placebo controlled phase Ⅱ trial ofcediranib (CED) plus carboplatin+paclitaxel (C+P) in advanced nonsmall cell lung cancer of any histology: Further analyses. J Thorac Oncol, 2008, 3 (suppl): S304.
  • 7Kim ES, Kies MS, Fosssella FV, et al. Phase II study of the farnesyltransferase inhibitor lonafarnib with paclitaxel in patients with taxane-refractory/ resistant non small cell luang carcinoma. Cancer, 2005, 104(3): 561-569.
  • 8Reck M, von Pawel J, Zatloukal P, et al. Phase Ⅲ trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAIL. J Clin Oncol, 2009, 27(8): 1227-1234.
  • 9Herbst RS, Blumenschein Jr GR, Kim ES, et al. Sorafenib treatment efficacy and KRAS biomarker status in the Biomarker-Integrated Approaches of Targeted Therapy for Lung Cancer Elimination (BATTLE) trial. Proc ASCO, 2010, 28: 15s (suppl; abstr 7609).
  • 10Scagliotti GV, Krzakowski M, Szczesna A, et al. Sunitinib (SU) in combination with Erlotinib (E) for the treatment of advanced/metastatic non-small cell lung cancer (NSCLC): a phase III study. Ann Oncol, 2010, 21(S8): viiil-viiil2 (Abstract LBA6).

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