支气管肺泡细胞癌术后生存状况分析

Prognostic Analysis of 58 Patients with Bronchioalveolar Carcinoma

目的：探讨影响支气管肺泡细胞癌（BAC）预后的临床病理因素。方法：收集我科2003年1月～2008年12月所有手术治疗并经病理证实的58例BAC患者的临床资料，采用Life-tables、Kaplan-Meier、Log-rank和COX比例风险模型等统计学方法，对患者术后的生存状况进行评价分析。结果：Life-tables分析结果显示，患者1～5a生存率逐年降低，其中位生存时间为55．35月；Log-rank分析显示，肿瘤的大小、淋巴结的转移情况、TNM不同分期以及影像和病理学不同分型对于BAC患者生存率的影响差异有统计学意义（P〈0．05）；肿瘤大小、TNM分期以及影像学和病理学分型是影响患者预后的独立危险因素。结论：肿瘤的大小、TNM分期以及影像学和病理学分型是影响BAC患者预后的独立危险因素；将BAC伴局部浸润和具有BAC特征的腺癌划为BAC值得商榷。

Objective： To investigate the clinicopathological factors associated with the prognosis of bronchioloalveolar carcinoma（BAC）. Methods ：58 BAC patients admitted our department from January, 2003 to December, 2008 were retrospectively analyzed. SPSS 13.0 software was used in Life - tables, Kaplan - Meier, Log - rank and COX regression analysis to analyze prognostic risk factors. Results： Lift - tables analysis confirmed the survival rate of 1 - 5 years decreased year by year, the median survival time（MST） was 55.35 months; Single survival analysis confirmed the survival was correlated to tumor size, lymph node, TNM stage, image typing and pathological typing, there were significant differences in the clinicopathological factors（ P 〈 0.05 ）. The results of multivariate analysis confirmed the tumor size, TNM stage, image and pathological typing were independent relevant factors. Conclusions：The tumor size, TNM stage, image and pathological typing were independent relevant factors to BAC patients ; It is debatable to regard the BAC with local invasion and the adenocarcinoma with characteristics of BAC as subtypes of BAC.