细胞膜电穿孔的机理及应用前景的初步探讨

Elementary Exploration of the Mechanism and Applicable Prospects of Membrane Electroporation

近年来 ,国内外众多学者就适当强度的脉冲电磁场作用下细胞膜发生电穿孔的现象展开了机理研究与应用实践。文中介绍了细胞膜电穿孔现象产生的前提条件 ,并且从细胞膜的电特性和机械特性变化、分子结构的变化以及对微粒和离子的跨膜运输能力的影响这三个角度展开对细胞膜电穿孔特性的机理研究。同时 ,还介绍了目前细胞膜电穿孔特性在生物技术和临床医学等领域的广泛应用以及对其进行机理研究的重要意义 。

Recently, more and more scholars join in the mechanism research and wide applications of membrane electroporation phenomenon. This paper introduces the electroporation precondition which leads to the numbers of pores in the membrane increased rapidly. It elaborates the mechanism research of membrane electroporation from three areas:namely the change of electric and mechanical characteristic of membrane, change of membrane molecular structure and the influence to ability of transmembrane transport of particles and ions. Moreover, this paper introduces the current wide applications of membrane electroporation characteristic in biologic technology and clinical medicine, emphasizes the significance of the mechanism research of membrane electroporation and lays out its favorable applicable prospects.