39302例患者不规则抗体筛查结果分析及其临床意义

The Analysis and Clinical Significance of Irregular Antibodies Screening for 39302 Patients

目的:对需要输血的患者进行输血前不规则抗体筛查,为受血者选择合适的供血者血液成份,确保临床输血安全有效地进行。方法:选择2009年10月1日～2011年10月31日在本院入院进行治疗性输血和手术备血的患者,采用微柱凝胶法对受血者进行血清中不规则抗体的筛查,并对筛查阳性标本进抗体特异性鉴定。确保临床输血安全有效。结果:在39302例受血者血清中共检测出不规则抗体69例(阳性率0.18%),其中抗-D 5例、抗-E 15例、抗-C 2例、抗-c 2例、抗-e 2例、抗-C,e 1例、抗-M 8例、抗-S 1例、抗-Lea2例、抗-Leb1例、自身抗体5例、25例未确定抗体的特异性。结论:不规则抗体筛查对保证输血安全、降低免疫性溶血性输血反应、及时寻找相容血液及预防和减少新生儿溶血病的发生很有必要。

Objective： To do the irregular antibodies screening for patients before blood transfusion and provide the matched blood components for blood recipients to ensure transfusion safety. Methods： All the patients hospitalized in this hospital during Oct 1, 2009 - Oct 31,2011 were taken therapeutically transfusion and operation-oriented blood preparation. We used micro-column gel agglutination assay to do the irregular antibodies screening for those patients to ensure the transfusion safety. Results： We find 69 irregular antibodies （0.18% positive rates） in the serum of all 39302 patients, including 5 anti-D, 15 anti-E, 2 anti-C, 2 anti-c, 2 anti-e, 1 anti-C,e, 8 anti-M, 1 anti- S, 2 anti- Lea, 1 anti- Leb, 5 autoantibodies and 25 uncertain antibody specificity. Conclusion： Irregular antibodies screening is utmost necessary for transfusion safety, immunological and hemolytic transfusion reaction, matching compatible blood and prevention of new-born babies＇ hemolytic disease.