良附胃漂浮片的制备及体外溶出度的研究

Preparation and in vitro Dissolubility of Liangfu Gastric Floadting Tablets

目的:研究良附胃漂浮片的处方,片剂的制备工艺和体外溶出度。方法:采用正交设计以羟丙基甲基纤维素(HPMC)、十六醇、碳酸氢钠、羧甲基淀粉钠(CMC-Na)为辅料,压片即得。并考察其体外溶出度及漂浮度。结果:漂浮片的迟滞时间小于5min,持续漂浮时间都大于12h,12h的累积释药量大于90%。结论:研制的良附胃漂浮片具有较好的漂浮特性和释药特性。

Objectives：To investigate prescription, preparation process and in vitro release of Liangfu stomach floating tablets. Methods ： The orthogonal design was used to determine the formulation containing the fiber （HPMC） and sixteenth alcohol, sodium carbonate hydrogen, the sodium starch sodium （CMC-Na） as adjuvant material, and in vitro release of and floating was tested. Results： The delay time was less than 5min, floating time was more than 12h, 12h of dose release reached more than 90 %. Conclusion： The Liangfu stomach floating tablets have good floating and release characteristics.