摘要
目的:研究良附胃漂浮片的处方,片剂的制备工艺和体外溶出度。方法:采用正交设计以羟丙基甲基纤维素(HPMC)、十六醇、碳酸氢钠、羧甲基淀粉钠(CMC-Na)为辅料,压片即得。并考察其体外溶出度及漂浮度。结果:漂浮片的迟滞时间小于5min,持续漂浮时间都大于12h,12h的累积释药量大于90%。结论:研制的良附胃漂浮片具有较好的漂浮特性和释药特性。
Objectives:To investigate prescription, preparation process and in vitro release of Liangfu stomach floating tablets. Methods : The orthogonal design was used to determine the formulation containing the fiber (HPMC) and sixteenth alcohol, sodium carbonate hydrogen, the sodium starch sodium (CMC-Na) as adjuvant material, and in vitro release of and floating was tested. Results: The delay time was less than 5min, floating time was more than 12h, 12h of dose release reached more than 90 %. Conclusion: The Liangfu stomach floating tablets have good floating and release characteristics.
出处
《世界中医药》
CAS
2012年第6期563-564,共2页
World Chinese Medicine
关键词
良附胃漂浮片
漂浮和释药
Liangfu stomach floating tablets
Floating and release