乙酰肝素酶及碱性成纤维细胞生长因子在子宫腺肌病中的表达及意义

Heparanase,Basic Fibroblast Growth Factor in Uteine Adenomyosis of the Expression and Significance

目的:探讨乙酰肝素酶(Heparanase,Hpa)和碱性成纤维细胞生长因子(Basic Fibroblast Growth Factor,bFGF)在子宫腺肌病中的表达及其临床意义。方法:免疫组化链霉亲和素生物素过氧化物(Strepta-vidin Biotin Complex,SABC)法检测32例子宫腺肌病患者的腺肌病病灶、异位内膜和在位内膜中Hpa、bFGF的表达,并与因子宫肌瘤行子宫切除术,经病理检查证实的正常的子宫内膜患者30例对照分析。结果:Hpa在子宫腺肌病患者的在位和异位内膜组织中的阳性表达率明显高于正常对照组,差异有统计学意义;子宫腺肌病患者在位内膜组bFGF阳性表达率显著高于对照组,差异有统计学意义;子宫腺肌病异位组与对照组bFGF阳性表达率无显著性差异。结论:Hpa、bFGF的表达说明两者在子宫内膜侵入子宫肌层的过程中起一定作用,为子宫腺肌病的预防和治疗提供理论依据。

Objective：Study of heparanase and basic fibroblast growth factor expression of Hpa and bFGF and its clinical signifiCance.Methods：The expression of Hpa and bFGF in ectopic endometrium,and eutopiC endometrium in 32 samples with adenomvosis and 30 normal endometrium was detected by immunohistochemistry（SABC）.Results：The positive expression rates of Hpa at the emopic and ectopic endometrial tissues of the patients with adenomyosis Signiticantly higher than the normal control group.Differences are statistically significant;the bFGF expressinonrates of the Adenomyosis Group eutopic endometrial in patientsSignificantly higher than the normal control group.Differences are statistically significant.Uterine glands myopathy rate of ectopic expreSSion of bFGF-positive Group and.control groups had no significant differences.Conclusions：Hpa and bFGF,can both significantly express in ectopic endometrium which were both the important cellular factors of promoting the vascular formation.bFGF and Hpa have the positive relativety in the ectopic endometrium.