阿立哌唑合并西酞普兰治疗难治性抑郁症

Aripira Ole Ombined with Italopram in the Reatment of Reatment Resistant Depression

目的:探讨阿立哌唑合并西酞普兰治疗难治性抑郁症的疗效。方法:将60例难治性抑郁症患者随机分成两组,分别给予阿立哌唑合并西酞普兰(合用组)及单用西酞普兰组(单用组)治疗12周,以汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)评定疗效,以治疗中出院的症状量表(TDSS)和相关检查评定不良反应。结果:治疗结束时两组HAMD和HAMA的评分均显著降低,以合用组疗效显著较好而快。结论:阿立哌唑合用西酞普兰治疗难治性抑郁症的疗效优于单用西酞普兰组,且耐受性好。

Objective：To explore the effect of aripirazole combined with citalopram in the treatment of treatment resistant depression.Method：60 patients with treatment resistant depression were randomly assigned into two groups,aripiprazole combined with citalopram and citalopram alone for 12 weeks.the clinical efficacy were evaluated by the Hamilton depressive scale（HAMD） and the Hamilton anxiety scale（HAMA）.Adverse events were assessed by the treatment emergent symptom scale（TESS） and related laboratory examinations.Results：As compared with the baseline scores,the HAMD scores,as well as HAMA scores,decreased significantly after 12 week＇s treatment（P0.05）,especially for the patients treated by combination of aripiprazole with citalopram.Conclusion：The combination of aripiprazole with citalopram is better than citaloprom alone in the treatment of treatment resistant depression.