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心型脂肪酸结合蛋白与急性脑梗死 被引量：2

Heart-Type Fatty Acid-Binding Protein and Acut Cerebral Infraction
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摘要 心型脂肪酸结合蛋白是一种可溶性细胞质蛋白,在脑细胞内有所表达。当病人患急性脑梗死时,早期心型脂肪酸结合蛋白水平明显升高,敏感性优于传统的生物学指标神经元特异性烯醇化酶(NSE)及S100B,浓度与脑梗死的面积和神经缺损功能相关联,有可能成为早期诊断脑梗死的新型生物学指标。 Heart-type fatty acid-binding protein is a soluble cytoplasmic protein,and expressed in the brain cells.The levels of heart-type fatty acid-binding protein were significantly increased in serum in the early stage of cerebral infarction,While pati-ents were suffering from acute cerebral infarction.it is more sensitive than conventional neuro-biochemical markers,named neuron specific enolase（NSE） and S100B.The concentrations of serum were associated with the areas and injured neurological functions.So it is potential to be a new type of neuro-biochemical markers for the early diagnosis of cerebral infarction.
作者 尚敏 王萍
机构地区 包头医学院研究生院
出处 《内蒙古医学杂志》 2012年第8期934-936,共3页 Inner Mongolia Medical Journal
关键词 心型脂肪酸结合蛋白 脑梗死 急性 Heart-type fatty acid-binding protein Cerebral infraction Acute
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献14

  • 1Chkaru Y, Asayama K, Isgii H, et al. Development of a sand- wichenzyme linked immu- nosorbent assay for the determination of human heart type fatty acid - binding protein in plasma and urine by using two different monocl onal antibodies specific for human heart fatty acid binding protein[J ]. Journal of Immunolog- ical Methods, 1995, (178):99.
  • 2Ockner RK, Manning JA. Fatty acid - hinging protein in small in- testine[J] .J Clin In - vest, 1984, 54(3) :326 - 338.
  • 3Gorski J, Hermens WT, Borawski J. Increased fatty acid - binding protein concentra - tion in plasma of patients with chronic ranal failure[J]. Clin Chem, 1997, 43:193.
  • 4Glatz JF, Storch J. Unravelling the significance of cellurlar fatty acid- binding proteins[J]. Curropin Lipido, 2001, 12(3) : 267 - 274.
  • 5Agata Chmurzynska. The multigene family of fatty acid - binding proteins (FABPs) : function, structure and polymorphism [ J ]. J Appl Genet, 2006,47(1 ) : 39 - 48.
  • 6Schaap FG, BinasB, DannebergH, et al. Impaired long- chain fatty acid utilization by cardiacmocytes isolated frommice lacking the heart - type fatty acid binding protein gene [ J ]. Circ Res,1999,85(4):329 - 337.
  • 7Maurice M. A. L. P, Thorsten H, Danie V. V, et al. Brain - type and Heart - type fatty acid - bin - ding proteins in the Brain: Tis- sue Distribution and Clinical Utility[J ]. Clinical Chemistry, 2004, 50(9):I 568-1 575.
  • 8Cathercine G, Zimmermann Lvol, Pierre R, et al. Fatty Acid Bind- ing Protein as serum marker for the early diagnosis of stroke[J ]. Molecular&Celluar Proteomics, 2004,12 : 66 - 72.
  • 9Wunderlich MT, Hanhoff T, Goertler M, et al. Release of brain - type and heart - type Fatty acid - binding proteins in serum after acute ischaemic stroke[J]. Journal of Neurology, 2005, 252, (6) : 1 432-1459.
  • 10Zimmermann - lvol CG, Burkhard PR, Le Floch - RohrJ, et al. Fatty acid binding protein as a serum marker for the early diagno- sis of stroke: a pilot study[J ]. Mol Ceil Proteomics, 2004, 3 (1): 66 - 72.

二级参考文献14

  • 1Wunderlich MT, Hanhoff T, Goertler M, et al. Release of braintype and heart-type fatty acid-binding proteins in serum after acute ischaemic stroke[ J]. J Neurol, 2005,252 (6) : 1432-1459.
  • 2Zimmerraann-Ivol C, Burkhard P, Le Floch-Rohr J, et al. Fatty acid binding protein as a serum marker for the early diagnosis of stroke: a pilot study[J]. Mol Cell Proteomics, 2004,3(1 ) : 66-72.
  • 3Reiber H. Proteins in cerebrospinal fluid and blood : barriers, CSF flow rate and source-related dynamics[ J ]. Restor Neurol Neurosci, 2003,21 (3-4) :79-96.
  • 4饶明俐.中国脑血管病防治指南(试行版)[C].卫生部疾病控制司和中华医学会神经病学分会,2005:1
  • 5Glatz JF,vander Vusse GJ,Simoons ML,et al.Fatty acidbinding protein and the early detection of acute myocardial infarction[J].Clin Chim Acta,1998,272(1):87-92
  • 6Cothercin G,Zimmermann-lvol,Pievrek,et al.Fatty Acid Binding protein as a serum marker for the early diagnosis of stroke[J].Molecular & Cellular Proteomics,2003,12:66-72
  • 7Wunderlich MT,Wallesch CW,Goertler M.Release of neurobiochemical markers of brain damage is related to the neurovascular status on admission and the site of arterial occlusion in acute ischemic stroke[J].J Neurol Sci,2004,227(1):49-53
  • 8Foerch C,Singer OC,Neumann-Haefelin T,et al.Evaluation of serum S100B as a surrogate marker for long-term outcome and infarct volume in acute middle cerebral artery infarction[J].Arch Neurol,2005,62 (7):1130-1134
  • 9Wunderlich MT,Hanhoff T,Goertler M,et al.Release of brain-type and heart-type fatty acid-binding proteins in serum after acute ischaemic stroke[J].Journal of Neurology,2005,252(6):1432-1459
  • 10Maurice MALP,Thorsten H,Danielle vander Voort,et al.Brain and heart-type fatty acid-binding proteins in the brain:tissue distribution and clinical utility[J].Clinical Chemistry,2004,50(9):1568-1575

共引文献25

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二级引证文献27

内蒙古医学杂志
2012年 第8期

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