肺癌患者肺部感染的易感因素、病原菌及药敏分析

Analysis of predisposing factors,pathogenic bacteria and their drug sensitivity of pulmonary infection in lung cancer patients

目的分析肺癌患者肺部感染的易感因素、病原菌变迁及药敏状况,为肺癌患者的抗感染治疗提供临床依据。方法对103例肺癌合并肺部感染患者易感因素、痰标本进行培养及药敏分析。结果 103例患者送检252份合格痰标本,其易感因素主要为年龄、住院时间、放化疗、临床分期。检出病原菌75株,其中真菌45.3%,革兰阴性菌44%,革兰阳性菌10.7%。6种主要病原菌对抗菌药物都具有不同程度的耐药性。结论加强肺癌患者肺部感染病原菌的监测,为临床合理使用抗菌药物提供参考依据。

Objective To analyze the predisposing factors, pathogenic bacteria and their drug sensitivity of pulmonary infection in lung cancer patients so as to provide clinical evidence for the anti-infective therapy of lung cancer. Methods The sputum samples of 103 patients with lung cancer complicated with pulmonary infection were cultured and given drug sensitivity test. Besides, the predisposing factors were analyzed. Results There were 252 qualified sputum samples, and 75 strains of pathogenic bacteria were detected, including 45.3% fungi, 44% Gram-negative bacteria, and 10. 7% Gram-positive bacteria. The 6 major kinds of pathogenic bacteria all showed different degrees of drug resistance. In addition, the major predisposing factors were age, duration of hospital stay, chemicotherapy and clinical stages. Conclusion The monitoring of pulmonary infection pathogenic bacteria should be strengthened in lung cancer patients, which can provide the basic clinical evidence for the use of antibacterials.