血清25-羟基维生素D_3浓度水平与成人支气管哮喘及COPD的相互关系

Relationship of the level of 25-hydroxy vitamin D3 in serum to asthma and COPD in adults

目的通过检测支气管哮喘、COPD患者血清25(OH)D3水平,分析其与两种疾病的关系。方法随机选择哮喘患者59例、COPD患者35例,与之年龄、性别等相仿的健康对照组49例。通过电化学发光法检测25(OH)D3水平,并分析成人哮喘及COPD患者与对照组血清25(OH)D3水平的差异性。检测哮喘患者肺功能指标,分析与25(OH)D3水平相关性,以P<0.05为有统计学意义。结果病例组血清25(OH)D3水平低于对照组,差异有统计学意义(P<0.05),哮喘患者血清25(OH)D3水平与FEV1、FEV1/FVC、FVC实测值之间无相关性(P>0.05)。结论支气管哮喘及COPD患者均普遍存在维生素D缺乏现象。在成人支气管哮喘患者低的25(OH)D3水平与其肺功能之间无相关性。

Objective To analyze the relationship of the level of 25-hydroxy vitamin D3 in serum to asthma and COPD in adults. Methods The study selected 59 patients with asthma and 35 patients with COPD as the treatment group, and 49 healthy people as the control group. The level of 25 （OH）D3 was detected by electrochemical luminescence method, and then the different levels of 25 （OH）D3 and their pulmonary function between the two groups were analyzed. Results The level of serum 25 （OH） D3 in the treatment group was lower than in the control group （ P 〈 0. 05 ）. There was no association between the level of serum 25 （OH） D3 and measured values of FEV1 , FVC, and FEV1/FVC in the treatment group （ P 〉 0. 05 ）. Conclusion There exists a low level of serum 25 （OH） D3 in patients with asthma and COPD, and it has no direct and significant relationship between the low level of serum 25 （OH）D3 and pulmonary function.