基层医院大肠埃希氏菌和肺炎克雷伯杆菌的分布及耐药分析

Distribution and drug resistance of escherichia coli and Klebsiella pneumonia in basic hospitals

目的探讨基层医院大肠埃希氏菌和肺炎克雷伯杆菌的分布和耐药性。方法采用常规方法进行菌株的分离和鉴定,根据美国临床实验室标准化委员会(NCCLS)相关文件判断结果。结果 246株大肠埃希氏菌和152株肺炎克雷伯杆菌对常用抗菌药物产生了不同的耐药性,大肠埃希氏菌和肺炎克雷伯杆菌产超广谱β-内酰胺酶(ESBLS)率分别为30.8%和18.4%,大肠埃希氏菌对亚胺培南的耐药率为0.4%,对氨苄西林的耐药率为78.0%;而肺炎克雷伯杆菌对亚胺培南的耐药率为0.0%,对氨苄西林的耐药率达96.1%。结论基层医院大肠埃希氏菌和肺炎克雷伯杆菌耐药性已十分严重,应开展耐药性监测。

Objective To discuss the drug resistance and distribution of the escherichia coli and Klebsiella pneumonia in basic hospitals. Methods The study used conventional methods to separate and identify the bacterial strain, and then the results were evaluated according to the National Clinical Laboratory Operational Regulations. Results 246 strains of escherichia coli and 152 strains of Klebsiella pneumonia showed different drug resistance to different antibacterials as follows ： taking the escherichia coli for example, its sensitivity to ESBLS was 30.8%, imipenem 0.4%, and ampicillin 78.0% ; while the sensitivity of Klebsiella pneumonia to ESBLS was 18.4%, imipenem 0.0%, and ampieillin 96. 1%. Conclusion The drug resistance of eseherichia coli and Klebsiella pneumonia in basic hospitals is very serious, so the surveillance of bacterial resistance should be launched in basic hospitals timely.