硝普钠联合垂体后叶素治疗肺结核大咯血的疗效观察

The curative effect observation of sodium nitroprusside combined with posterior pituitary hormone in the treatment of massive hemoptysis of pulmonary tuberculosis

目的观察和比较硝普钠联合垂体后叶素治疗肺结核大咯血的临床疗效。方法 52例肺结核大咯血患者随机分为两组,对照组(n=26)仅采用垂体后叶素治疗,观察组(n=26)则采用硝普钠联合垂体后叶素治疗。观察和比较两组患者的临床疗效和不良反应。结果观察组治疗总有效率(92.3%)明显高于对照组(73.1%)(P<0.05);观察组止血时间明显较对照组缩短(P<0.05);两组不良反应发生率比较无明显差异性(38.5%,46.2%,P>0.05)。结论硝普钠联合垂体后叶素治疗肺结核大咯血疗效显著,不良反应少,值得临床推广应用。

Objective To observe and compare the clinical efficacy and adverse reaction of sodium nitroprusside combined with posterior pituitary hormone in the treatment of massive hemoptysis of pulmonary tuberculosis. Methods 52 patients of pulmonary tuberculosis hemoptysis were randomly divided into two groups ： the control group （ n = 26 ） was only treated with posterior pituitary hormone, and the observation group （ n = 26） was treated with sodium nitroprusside combined with posterior pituitary hormone. The clinical efficacy and adverse reaction of the two groups were observed and compared. Results The total effective rate of the observation group （92. 3% ） was significantly higher than that of the control group （73.1% ） （ P 〈 0. 05 ）. The hemostasis time of the observation group was significantly shortened than that of the control group （ P 〈 0.05 ）. The incidence of adverse reactions in the two groups had no significant difference （38.5%, 46. 2%, P 〉 0. 05 ）. Conclusion The treatment of sodium nitroprusside combined with posterior pituitary hormone for the massive hemoptysis of pulmonary tuberculosis has better curative effect and less adverse reaction, so it is worthy of clinical application.