卡维地洛治疗慢性充血性心衰临床疗效及安全性研究

目的探讨卡维地洛用于慢性充血性心衰治疗的临床疗效及安全性。方法选取治疗的慢性充血性心衰患者102例,随机分为观察组和对照组,对照组给予常规抗心衰治疗,观察组加用卡维地洛进行治疗,比较疗效。结果观察组有效率为96.08%,对照组有效率为82.35%,P<0.05,差异有统计学意义。观察组LVE(F45.43±3.21)%,LVEDD(50.17±2.96)mm,LVESD(41.52±3.31)mm,对照组LVE(F38.86±3.54)%,LVEDD(60.36±3.21)mm,LVESD(51.03±3.22)mm。观察组LVEF明显高于对照组,LVEDD和LVESD明显低于对照组(P<0.05),两组不良反应发生率无显著差异(P>0.05)。结论卡维地洛用于慢性充血性心衰的临床治疗,安全有效,可明显改善心功能。

Objective To investigate the effects and safety of carvedilol for chronic congestive heart failure therapy. Methods 102 cases of chronic congestive heart failure in our hospital were randomly divided into observation group and control group. The control group was given routine anti heart failure treatment, the observation group combined with carvedilol. Effects and satety were compared. Results. The efficency of the observation group was 96.08%, while the control group was 82.35%, P〈0.05, the difference was significant. LVEF of the observation group was （45.43±3.21）%,LVEDD was （50.17±2.96）mm,LVESD was（41.52±3.31 ）ram; LVEF of the control group was（38.86±3.54）%,LVEDD was （60.36±3.21）mm,LVESD was（51.03±3.22）mm. LVEF of the observation group was higher than that of the control group, LVEDD and LVESD were significantly lower than those of the control group（P〈0.05）, the incidence of adverse reactions of two group was no significant difference（P〉0.05）. Conclusion It was safety and effective for Carvedilol in chronic congestive heart failure clinical treatment. Carvedilol can improve the heart function Obviously.