乳果糖口服液对慢性功能性便秘患者血浆胃动素和一氧化氮水平的影响

The effect of lactulose oral solution on plasma levels of motilin and NO of patients with chronic functional constipation

目的探讨乳果糖口服液对慢性功能性便秘患者血浆胃动素(MTL)和一氧化氮(NO)水平的影响及疗效观察。方法将80例慢性功能性便秘患者随机分为观察组和对照组。两组患者均给予调节饮食及排便锻炼等基础治疗。观察组在上述基础上加用乳果糖口服液10 g,(2～3)次/d,连用6周。结果治疗3、6周后,两组患者血浆MTL水平较治疗前明显上升,血浆NO水平较治疗前明显下降(P<0.05或P<0.01),且观察组上升或下降程度较对照组更显著(P<0.05);同时观察组的总有效率明显高于对照组(χ2=8.35,P<0.01)。两组治疗期间无明显严重的药物不良反应。结论乳果糖口服液治疗慢性功能性便秘疗效确切,安全性较好,作用与促进体内MTL释放和降低NO合成密切相关。

Objective To observe the effect of lactulose oral solution on plasma levels of motilin and NO of patients with chronic functional constipation and its clinic effect. Methods All of 80 patients with chronic function constipation were randomly divided into observing group and control group. All of the patients got treatment as diet adjusting, defecating exercise and so on. The observing group got extra treatment as taking lactulose oral solution 10 g 2 to 3 times per day, for 6 weeks. Results Three or six weeks after treatment, the level of MTL of both the two groups rose significantly compared with that before treatment, but the level of NO was opposite （P 〈 0.05 or P 〈 0.01）, and the range of rising or decreasing were more obvious in observing group （P 〈 0.05）. The total effective rate of observing group was significant higher than that of control group （X2= 8.35 ,P 〈 0.01）. There was no obvious side effect observed during the treatment from the two groups. Conclusion Lactulose oral solution maybe an ideal drug to treating patients with chronic functional constipation for its certain clinic curative effect and high-safety. Its mechanism may relate closely to MOT release increasing and NO synthesisdecreasing.