复方甘草酸苷联合非索非那定治疗玫瑰糠疹疗效分析

Curative effect analysis of Compound glycyrrhizin and Fexofenadine on Pityriasis rosea

目的探讨复方甘草酸苷联合非索非那定治疗玫瑰糠疹的临床效果。方法分析我院皮肤科自2011年1月～2012年1月收治的76例玫瑰糠疹患者。按随机数字表法分为观察组及对照组。观察组40例给予复方甘草酸苷联合非索非那定,对照组36例给予非索非那定。两组均以14 d为一个疗程。比较两组患者的总体疗效及不良反应的发生率。结果两组临床总有效率分别为92.5%(37/40)、80.5%(29/36),两组比较差异有统计学意义(χ2=4.18,P<0.05)。两组未出现严重不良反应,临床不良反应发生率分别为15.0%(6/40)、11.1%(4/36),两组比较差异无统计学意义(χ2=0.25,P>0.05)。结论复方甘草酸苷联合非索非那定辅助治疗玫瑰糠疹效果理想,并不增加临床不良反应的发生率,值得临床推广使用。

Objective To evaluate the effectiveness of compound glycyrrhizin and Fexofenadine on pityriasis rosea. Meth- ods A total of 76 cases of patients with pityriasis rosea from department of dermatology in our hospital were analyzed from January 2011 to January 2012.76 eases were divided observation group （40 cases）which used compound glyeyrrhizin and fexofenadine,and control group （36 cases） which used fexofenadine by random number table. There were 14 days a course of treatment in two groups. Two groups of patients were discharged on the overall efficacy and adverse reaction rate. Resuits Two groups of clinical total effective rate were 92.5% （37/40）, 80.5% （29/36）, comparison of the two groups was statistically （X2=4.18,P 〈 0.05）. There was not serious and harmful response in two groups,clinical adverse reaction rates were 15.0%（6/40）, 11.1%（4/36）,comparison of the two groups was statistically （X2=0.25 ,P 〉 0.05）. Conclusion The effect of compound glycyrrhizin and fexofenadine in adjuvant treatment of pityriasis rosea is satisfactory, does not increase the incidence of clinical adverse reaction, is worthy of clinical use.