卡维地洛治疗慢性心力衰竭并心律失常的疗效观察

Curative effect of carvedilol in treatment of chronic heart failure with arrhythmia

目的观察卡维地洛治疗慢性心力衰竭并发心律失常的临床疗效。方法收集笔者所在医院2010年1月～2011年12月收治的慢性心力衰竭合并室性心律失常的患者84例,随机分为治疗组和对照组,每组各42例。对照组予以强心、利尿药、血管转换酶抑制剂、血管扩张剂等常规抗心衰及抗心律失常药物治疗。治疗组在对照组治疗基础上加用卡维地洛治疗,比较两组患者的近期疗效及远期疗效。结果治疗组治疗2周后的总有效率为95.24%,对照组为85.72%,治疗组明显高于对照组,差异有统计学意义(P<0.05)。用药3个月后,两组患者治疗前后超声心动图变化情况比较显示,两组治疗后明显优于治疗前,治疗组超声心动图参数改善状况明显优于对照组,差异均有统计学意义(P<0.05)。结论卡维地洛治疗慢性心力衰竭合并室性心律失常疗效肯定,可减少心律失常的发生,明显改善心功能,值得临床推广使用。

Objective To observe the curative effect of carvedilol in treatment of chronic heart failure with arrhythmia. .Methods Collected 84 cases of chronic heart failure patients with ventricular arrhythmias from January 2010 to December 2011, were. randomly divided into treatment and control groups, 42 cases in each group. The control group was given the strong heart, diuresis medicine, ACEI, vasodilators and other routine anti heart failure and antiarrhythmic drug therapy. The treatment group were treated with carvedilol. The recent efficacy and long-term effect were compared. Results After two weeks, the total effective rate of treatment group was 95.24%,in the control group was 85.72%, the treatment group was significantly higher, thedifference was statistically significant（P 〈 0.05）. After 3 months, treatment group of the ultra- sound ：heartbeat graph parameters to improve the situation significantly better than the control group, the difference was statistically significant（P 〈 0.05）. Conclusion Carvedilol in treatment of chronic heart failure complicated with ventricular arrhythmias, can reduce the occurrence of arrhythmia, improve cardiac function, is worthy of clinical use.