茵栀黄口服液治疗黄疸型婴儿肝炎综合征疗效观察及安全性评估

Clinical effects and safety assessment of Yinzhihuang Oral liquid on infantile hepatitis syndrome

目的评价茵栀黄口服液治疗黄疸型婴儿肝炎综合征的临床疗效与安全性。方法将98例黄疸型婴儿肝炎综合征患者随机分为两组,对照组49例采用普通保肝治疗;治疗组49例,在对照组基础上加用茵栀黄口服液进行治疗。比较两组治疗后的临床疗效与丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)及总胆红素(TBil)变化情况,同时观察肝脏与脾脏大小变化。结果观察组治愈27例,好转18例,总有效率91.84%;对照组治愈17例,好转15例,总有效率65.31%,观察组总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗后观察组ALT、AST与TBil浓度水平均明显下降,且浓度恢复接近正常水平,与对照组相比差异有统计学意义(P<0.05);治疗后,观察组肝脏回缩较对照组有明显改善,差异有统计学意义(P<0.05);两组患儿用药后均无明显副反应发生。结论茵栀黄口服液治疗黄疸型婴儿肝炎综合征具有显著退黄作用,能使肿大的肝脏明显缩小,临床应用安全有效。

Objective To contrast and evaluate of Yinzhihuang Oral liquid on infantile hepatitis syndrome in efficacy and safety. Methods A total of 98 patients with infantile hepatitis syndrome were randomly divided into treatment group and control group. The treatment group was treated with Yinzhihuang Oral liquid. Comparison of the clinical efficacy of the itwo groups and the level of alanine transaminase（ALT）, aspartate aminotransferase（AST）and total bilirubin（TBil）and the ehm＇rge of liver and spleen. Results 27 cases of the observation group were cured, 18 cases improved, the total effective rate was 91.84% ; 17 cases were cured of the control group, 15 cases improved, the total efficiency of 65.31%. Compared to two groups, the observation group was better than that in control group, the difference was significant（P 〈 0.05） ;After treatment, the observation group ALT, AST and TBil concentration level were significantly decreased, and the concentration recovery close to normal level, compared with the control, significant difference（P〈 0.05）;After treatment, the observation group liv- er rebound a control group were obviously improved, with significant difference （P 〈 0.05） ;Two groups of children after drugs are no significant side effects occur： Conclusion Yinzhihuang Oral liquid can make the swollen liver apparently con- tractible, also it is clinical safe and effective to infantile hepatitis syndrome.