食物不耐受与人体免疫功能关系探讨

Food intolerance and human immune function

目的探讨食物不耐受在体检人群中的检测现状及对机体免疫、炎症指标的早期影响。方法采用酶联免疫吸附法对257例体检人群的血清标本进行食物特异性IgG抗体检测，比较检测结果阳性组和阴性组血白细胞、嗜酸性粒细胞、球蛋白、红细胞沉降率（ESR）、C反应蛋白（CRP）、类风湿因子（RF）、抗核抗体（ANA）及T细胞功能差异。采用SAS软件对相关资料进行t检验或卡方检验。结果257例受检人群中，食物特异性IgG抗体阳性134例，阳性率为52．14％。排名前三位的阳性食物分别是鸡蛋、螃蟹、牛奶，中、重度不耐受食物主要是鸡蛋和牛奶。比较食物不耐受检测阳性组和阴性组的血嗜酸性粒细胞、球蛋白水平，差异均有统计学意义（t=-0．07,x2=8．91，P〈0．05）；比较两组血白细胞、ESR、CRP、RF、ANA及T细胞功能，均差异无统计学意义（P〉0．05）。结论在临床症状或慢性疾病发生之前，食物不耐受人群的血嗜酸性粒细胞、球蛋白有明显升高，建议加强对这些人群的监测；而对机体血白细胞、ESR、CRP、RF、ANA及T细胞功能等免疫炎症指标无明显影响。

Objective To discuss current detection of food intolerance in health check-up populations and the influence of food intolerance on immune system and inflammation parameters. Methods Serum levels of 14 kinds of food-specific IgG antibodies were analyzed by using enzyme linked immunosorbent assay （ ELISA ） among 257 healthy check-up aduhs. White blood cell count, eosinophils, globulin, erythrocyte sedimentation rate （ ESR ）, C-reactive protein （ CRP ）, rheumatoid factor （ RF ）, antinuclear antibodies （ANA） and T cell function were compared between the positive group and the negative group. Student＇s t test and Chi-square test were used for data analysis. Results Food-specific IgG antibodies were found in 134 participants （52. 14% ）. The most common intolerant foods were egg,crab and milk. Moderate to severe food intolerance was caused by egg or milk. There was significant difference in eosinophils and serum globulin between the positive and the negative group （ t = - 0. 07, X2 = 8. 91, both P 〈 0. 05）. However,no difference was observed in white blood cell count, ESR, CRP, RF, ANA and T cell function between two groups （ all P 〉 0. 05 ）. Conclusion Eosinophils and serum globulin may significantly increased in people with food intolerance, although white blood cell count, ESR, CRP, RF, ANA and T cell function could be normal.