基于小分子的核酸结构探针最新研究进展

Recent progress of nucleic acid probes based on small molecules

本文主要综述了基于小分子的核酸结构探针的最新研究进展.所探索的核酸结构主要有四链核酸(包括G-四链体以及i-motif)结构、三链核酸结构、左手螺旋DNA结构以及不规则核酸结构(包括突起结构以及环状结构)等;所探索的小分子包括过渡金属配合物、大环共轭化合物、环肽以及寡糖抗生素等.

This paper reviews the latest research progress of the nucleic acid probes based on small molecules.The related nucleic acid structures include quadruplex nucleic acids（including G-quadruplex and i-motif）,triple-stranded nucleic acid structures,left-handed DNA helix structures,as well as irregular nucleic acid structures（bulge structures and loop structures）.The related small molecules includ transition metal complexes,the macrocyclic conjugated compounds,cyclic peptides,and oligosaccharide antibiotics.