摘要
目的:观察序贯疗法根除幽门螺杆菌的疗效,探讨提高幽门螺杆菌根除率的有效方法。方法:我院2010年2月~12月间经胃镜病理及快速尿素酶试验诊断幽门螺杆菌阳性589例,其中第一次根除Hp治疗失败患者102例。将其随机分为治疗组和对照组。治疗组(50例)采用埃索美拉唑+阿莫西林+克拉霉素+替硝唑的序贯疗法治疗,对照组(52例)采用埃索美拉唑+可乐必妥+克拉霉素+替硝唑的标准四联疗法治疗。结果:治疗后停药4周复查,治疗组的临床有效率(92%)显著高于对照组(73%)(P〈0.05)。治疗组复查Hp,48例阴性,2例阳性,根除率96%。对照组复查Hp,36例阴性,16例阳性,根除率为69.2%。2组间根除率存在显著性差异(P〈0.05)。结论:最新的序贯疗法是一个高效的根除方案。
Objective:To explore the effect of sequential therapy on improving Helicobacter pylori(Hp)eradica- tion rate and reducing the recurrence.Methods:From February 2010 to December 2010,Hp positive patients were 589 in the hospital through the menstrual gastro-endoseopic pathological and rapid urease test diagnosis. In this paper,after the first time for anti-Hp treatment,102 cases were still positive.They were randomly divid- ed into sequential therapy treatment group (50 cases)and control group (52 cases)The treatment group were treated with esomeprazole+amoxicillin+clarithromycin+tinidazole sequential therapy,in the control group with es- omeprazole +levofloxaein+elarithromyein +tindazole therapy.Results :After treatment,clinical total effective rate of treatment group (92%)was significantly higher than that of control group (73% ,P〈0.05).After treatment,the treatment group review Hp,48 were negative,2 were positive ,eradication rate was 96%.The control group re- view Hp,36 were negative,16 eases were positive,eradication was 69.2%.Eradication rate between the two groups had significant differences (P〈O.OS).Conclusion:The latest treatments sequential therapy is a highly ef- fective eradication program and has broad prospects for treatment.
出处
《中日友好医院学报》
2012年第6期323-325,共3页
Journal of China-Japan Friendship Hospital
关键词
幽门螺杆菌
治疗
序贯疗法
Helicobacter pylori
treatment
sequential therapy