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姜黄素对吲哚美辛诱导的大鼠胃病模型胃黏膜保护作用的研究

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摘要 目的探讨姜黄素对吲哚美辛诱导的大鼠胃病模型的胃黏膜的保护作用。方法 Wistar大鼠18只随机分为A组(对照组)、B组(吲哚美辛组)、C组(吲哚美辛+姜黄素组)各6只,实验结束时处死大鼠,测定血清细胞间粘附分子-1和肿瘤坏死因子-α水平及组织学检查。结果 B组血清ICAM-1、TNF-α水平较A组明显升高,组织学损伤较A组明显加重;C组血清ICAM-1、TNF-α水平较B组明显降低,组织学损伤较B组明显减轻。结论姜黄素对吲哚美辛诱导的大鼠胃病模型胃黏膜具有保护作用。
作者 陈周峰 黄智铭
机构地区 温州医学院附属第一医院
出处 《浙江实用医学》 2012年第5期318-318,327,392,共3页 Zhejiang Practical Medicine
关键词 姜黄素 吲哚美辛 大鼠胃病模型
分类号 R-332 [医药卫生]
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浙江实用医学
2012年 第5期

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