HBV、HCV重叠感染血清病毒标志物变化及与临床的关系

Changes of Sera Viral Marker in HBV and HCV Superinfection and the Clinic Significance

目的 :探讨 HBV、HCV重叠感染时 ,病毒之间的相互作用及其与临床的关系。方法 :应用 EL ISA法检测30例 HBV、HCV重叠感染患者血清病毒标志物 ;应用 PCR法检测 HBV DNA及 HCV RNA。结果 :与单纯 HBV或HCV感染患者相比 ,重叠感染患者 HBe Ag、HBV DNA、HCV RNA阳性率明显降低 ,抗 - HBe阳性率明显升高 ,HBs Ag、抗 - HBc Ig G及抗 - HCV平均几何滴度也明显降低 ,部分患者 HBs Ag阴转。重叠感染患者 TBil及 AST/AL T比值明显高于单纯感染者 ,尤以抗 - HBe阳性者明显。结论 :HBV、HCV感染同一宿主时存在相互干扰、相互抑制 ,且较单纯感染患者病情重。重叠感染时抗 -

Objective:Our aim was to investigate the viruses interaction in HBV and HCV superinfection and its clinic feature. Methods:Sera viral markers of 30 patients with HBV and HCV supeninfection were tested using ELISA method. HBV DNA and HCV RNA were detected using PCR method. Results:Compared with these of the patients with HBV or HCV single infection, the positive rates of HBeAg, HBV DNA, and HCV RNA in patients with superinfection were lower. The positive rate of anti HBe was higher. The average titers of HBsAg, anti HBV IgG, and anti HCV were significantly lower. For some patients, HBsAg was negative. The quantity of TBil and the ratio of AST/ALT were higher in superinfection than those in single infection, specially in the anti HBe positive group. Conclusion: Interference existed between HBV and HCV. Liver demage was more serious in superinfection than that in single infection. Positive anti HBe in superinfection did not mean the recovery from the disease.