贫血在慢性阻塞性肺疾病稳定期中发生机制的临床研究

Clinical study of the mechanism of anemia in chronic obstructive pulmonary disease in the stability period

目的:分析贫血在慢性阻塞性肺疾病稳定期中的作用。方法:纳入我院2009年1月至2012年1月期间门诊、呼吸内科慢性阻塞性肺疾病伴有贫血的患者共70例。所有患者按贫血标准分为两组,即正常血红蛋白组和贫血组。记录患者一般情况,包括年龄、性别、是否吸烟、身高、体重指数、住院时间等。记录入组当天的血常规、C反应蛋白、降钙素原、动脉血气结果,测定入组当天肺通气功能。结果:两组患者的年龄、体重指数、住院时间比较无显著性差异(P>0.05)。比较两组肺功能、C反应蛋白、降钙素原、动脉血气情况,入组当天两组肺功能(FEV1%)、PaO2无显著性差异(P>0.05),贫血组的入组当天CRP、PCT含量及PaCO2与正常组比较,明显升高(P<0.05)。结论:慢性阻塞性肺疾病患者伴有贫血可能与机体炎症反应有关,纠正该类患者贫血状态对于改善病情有帮助。

Objective：To analyze the rote of anemia in chronic obstructive pulmonary disease in the stability period. Methods： A total of 70 patients of chronic obstructive pulmonary disease with anemia were included during the out-patient hospital from Jan 2009 to Jan 2012 in department of respiratory medicine. All anemia patients were divided into two groups, the normal hemoglobin group and the anemia group. Age , gender, smoking , height , weight , length of stay were recorded,and also C-reactive protein, procalcitonin, arterial blood gas results. Pulmonary function and body mass index （BMI） were recorded in the first day. Results： Age, body mass index, duration of hospitalization between two groups was no significant difference （P〉0.05）,lung function（ PEV1% ）, PaO2 were also no significant difference （P〉0.05） in the first day,and CRP,PCT and PaCO2 was higher in the anemia group. Conclusion： Anemia patients with chronic obstructive pulmonary disease may be have inflammatory response, and it was helpful to correct anemia in these patients in order to improve the condition.