妊娠晚期凝血功能指标检测的变化及临床意义

目的:探讨妊娠晚期妇女体内凝血功能相关指标的变化及其临床意义。方法:选取2011年9月～2012年6月我院妇产科就诊的妊娠晚期妇女100例。并选取同期体检的健康妇女100名,作为对照组。清晨采集空腹静脉血,在STA-R-EVOLUTION全自动凝血分析仪上分析样本的凝血酶原时间(PT)、部分活化凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)、国际标准化比值(INR)。D-二聚体(DD)、纤维蛋白降解产物(FDP)采用免疫比浊法。结果:活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、D-二聚体(DD)、纤维蛋白原(FIB)、国际标准化比值(INR)、血浆纤维蛋白(原)降解产物(FDP)对比有显著差异,差异有统计学意义,P<0.05。凝血酶时间(TT)对比差异无统计学意义,P>0.05。结论:妊娠晚期孕妇处于高凝状态,分娩前需要动态监测孕妇的凝血功能,做好各种并发症的预防和抢救措施,最大限度地减少并发症。

objective：To explore the changes of coagulation function indexes and clinical significance on late pregnancy women. Methods： During Sep 2011 to Jun 2011, 100 late pregnancy were selected in our hospital. And 100 healthy women on health examination were selected as control group. CoUect the fasting venous blood in moring, test the PT、APTY、TY、FIB、INR on STA-R-EVOLUTION automatic coagulation analyzer. DD、FDP were tested by immnne turbidimetry. Results： There were significant difference between two groups in PT、APTT、FIB、INR、DD、FDP, P〈0.05. There was no significant difference between two groups in TT, P〉0.05. Conclusion： terminal pregnant women are in hypercoagulable state, it is definitely sure to dynamically monitor coagulation function of preganant women, prepare the preventive and rescue measures, reduce complication to minimum.