阿片受体克隆研究新进展

The new development of the research on cloning of the opioid receptors

阿片肽是一类结构相似的神经调质，通过神经系统的膜受体对疼痛起重要的调控作用。阿片受体可分为μ、δ、κ３种类型，它们之间既有相同点，又有各自不同的药理特性、解剖定位和功能特性。阿片受体克隆成功打开了将重组ＤＮＡ技术运用到受体水平的通路。本文以克隆受体为主题，集中讨论阿片受体的分子克隆和功能特性，在分子水平上对阿片肽的识别和信号转导机制做一初步探讨。

Opioid peptide is one sort of neuromodulators which have similar constructions. They act as important nociceptive pathways controller through membrane receptors of the nervous system. There are three kinds of opioid receptors: mu, delta and kappa. They have similar features and distinct pharmacological, anatomical and functional properties. The successful cloning of an opioid receptor gene family has made it possible to use recombinant DNA technology at the receptor level. The opioid receptor is focused on, their molecular cloning and functional characterization are discussed, and the recognition of opioid peptide and signal transduction mechanisms are described primarily on the molecular level.