卡维地洛对麻醉犬血流动力学的影响

Haemodynamic effects of carvedilol on anaesthetized dogs

目的 观察国产卡维地洛（ｃａｒｖｅｄｉｌｏｌ，Ｃａｒ）对动物血流动力学的影响，全面了解该药对心血管系统的作用。方法 杂种家犬麻醉下ｉｖ０－１、０－３、１ｍｇ·ｋｇ－１Ｃａｒ，记录心电、血压、左心室内压、心输出量。结果 Ｃａｒｉｖ给药可引起麻醉犬平均动脉压、心率、左心室内压及其最大变化速率、左心室做功及总外周血管阻力明显下降，给药后１ｍｉｎ即开始起效，给药后１～５ｍｉｎ达最大效能，并具有剂量依赖性，１ｍｇ·ｋｇ－１剂量药效可持续至给药后４５ｍｉｎ，Ｃａｒ对心输出量及左室舒张末压无明显影响。结论 Ｃａｒ具有较广泛的心血管效应，除通过扩张外周阻力血管降低血压外，尚具有降低心率、抑制心肌收缩性能的作用；试验结果同时提示国产Ｃａｒ兼具α肾上腺素受体和β肾上腺素受体拮抗作用，支持该药为具有Ｓ（－）和Ｒ（＋）构型的外消旋化合物。

AIM To observe the hameodynamic effects of carvedilol(Car) on intact animals and to investigate the affection of this drug on cardiovascular system. METHOD 0 1,0 3,1 0 mg·kg -1 Car was intravenously administered in 8 anaesthetized mongrel dogs, mean artery blood pressure(MAP),left ventricular pressure(LVP),cardiac output(CO) and the ECG was recorded. RESULTS Car can significantly and dose dependently decrease MAP, HR, LVP, LVP±d p /d t max , left ventricular work(LVW) and total peripheral resistance(TPR). For 1 0 mg·kg -1 the effects can be observed at 1 min after Car was given, achieved the maximum at 1～5 min and can last for 45 min. CONCLUSION Car has many effects on the cardiovascular system, besides the fallen MAP induced by the TPR reduction, Car can also decrease the HR and inhibit the contraction ability of the heart. The results also confirmed that Car would be a racemic mixture of the S (-) and R (+) enantiomers with the properties of both β blocking and α blocking agents.