甲苄基不对称三甲川菁染料的合成及光谱性能

Synthesis and Properties of N-4-methylbenzyl Trimethine Cyanine Dye

以对肼基苯磺酸和3-甲基-2-丁酮为原料经催化合成2,3,3-三甲基-3H-吲哚-5-磺酸,进一步制得钾盐。经钾盐合成N-甲苄基取代吲哚季铵盐。采用一步法将钾盐与吲哚季铵盐缩合为一种不对称三甲川菁染料,并考查其光谱性能。所合成染料经C-18反相柱分离提纯,利用核磁共振氢谱进行了结构表征。

2,3,3-Trimethyl-3H-indole-5-sulfonic acid was synthesized using 4-hydrazinylbenzenesulfonic acid and 3-methyl-2-butanone in acidic medium. 2,3,3 Trimethyl-3H-indoleninium-5-sulfonate and N-4-methylbenzyl-2,3,3-trimethyl-3H-indoleninium-5-sulfonates were synthesized. The title water soluble trimethine cyanine dye was synthesized by one step and purified by C18 reverse phase column chromatograph. The structure of the title dye was confirmed by 1HNMR. The spectral properties of the title dye were detected.